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pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of CYP3A4 inducers may well lessen sufentanil ranges and efficacy, quite possibly precipitating withdrawal syndrome in individuals that have formulated Bodily dependence to sufentanil. Disconti